It is hepatically converted to 25-hydroxyvitamin D (25OH-D) and transformed in the kidneys by renal 1a-hydroxylase into the biologically active form 1,25-dihydroxy-vitamin-D (1,25(OH)2-D3), i.e., calcitriol/cholecalciferol. Vitamin D is a steroid hormone, mainly produced by the skin upon exposure to sunlight, with less than 20% provided by alimentary sources. Highest AMH concentrations were found between August and October and this quartile was associated with highest D3 concentrations. Our data indicate seasonal 3-month quartile variations of AMH concentrations and characteristics of ART, such as days of ovarian stimulation and number of fertilized oocytes. However, no such differences were found for the numbers of MII oocytes or pregnancy rates. 4.97 p = 0.05) along with a trend towards higher numbers of cumulus–oocyte complexes.

12.12 days p = 0.042), higher number of fertilized oocytes between August and October (6.23 vs. 1.78 ng/ml p = 0.010) and these were associated with significantly shorter stimulation periods during August–October (11.29 vs. Similar seasonal dynamics were found for AMH (2.98 vs. Resultsĭ3 concentrations showed significant fluctuations within annual quartiles with a pronounced peak in August–October and a minimum in February–April (26.0 vs. Results were evaluated with respect to seasonal quartiles and outcome of the ART cycles. D3 as well as the AMH serum concentrations were measured at the beginning of the follicle stimulation (days 3–5 of menstrual cycles). We studied 469 female patients, presenting between 20 for ART treatment in our fertility center.

In this study, we analyzed D3 serum concentration in IVF/ICSI patients with respect to seasonal 3-month quartiles and anti-Muellerian hormone (AMH) referring to the impact on Assisted Reproductive Technologies (ART) outcome. Seasonal changes of D3 concentrations are well known however, they are not always considered in the context of reproductive functions. Recent studies revealed intriguing associations between cholecalciferol (D3) and reproductive functions.

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